Circulating markers of anti oxidant status in salt sensitive hypertension

Increased levels of atherosclerosis markers in salt-sensitive hypertension.

BACKGROUND Salt sensitivity in essential hypertension is associated with both endothelial dysfunction and increased cardiovascular risk. We evaluated several serum markers of atherosclerosis and endothelial function in a group of essential hypertensive patients classified on the basis of their salt sensitivity. METHODS Forty-three patients were classified as having salt-sensitive (20 subjects...

Atorvastatin prevents end-organ injury in salt-sensitive hypertension: role of eNOS and oxidant stress.

Statins, inhibitors of cholesterol biosynthesis, are endowed with pleiotropic effects that may contribute to their favorable clinical results. Hypertensive Dahl salt-sensitive (DS) rats have endothelial dysfunction and cardiorenal injury associated with decreased NO bioavailability and increased superoxide (O2-) production linked to a functional upregulation of angiotensin II. We investigated w...

Development of Salt-Sensitive Hypertension in Hydronephrosis

Salt Sensitive Hypertension and Orexin

Patients With Salt-Sensitive Hypertension

Twenty-two patients with normal plasma renln and essential hypertension were classified as "salt-sensitive" (SS) (n=9) or "non-salt-sensitive" (NSS) (n=13) from an increase in mean blood pressure with changes in sodium intake from 25 to 250 meq/day. With the high sodium diet, the SS patients gained more weight (/?<0.05), retained more sodium (/><0.05), and had a greater increase in cardiac outp...